Download e-book for iPad: Basal Ganglia and Thalamus in Health and Movement Disorders by Anne B. Young, John B. Penney (auth.), Kristy

By Anne B. Young, John B. Penney (auth.), Kristy Kultas-Ilinsky, Igor A. Ilinsky (eds.)

ISBN-10: 1461354544

ISBN-13: 9781461354543

ISBN-10: 1461512352

ISBN-13: 9781461512356

This quantity is made from the vast majority of lecture shows and some opt for posters offered on the overseas Workshop, "Basal Ganglia and Thalamus in wellbeing and fitness and stream Disorders," held in Moscow, Russia, on may possibly 29-31, 2000. The foreign Committee liable for organizing this workshop incorporated Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of clinical Sciences, Mahlon DeLong, Chair, division of Neurology, Emory collage, Atlanta, united states, Alim Louis Benabid, leader, Neurosurgery provider, collage of Joseph Fourrier, Grenoble, France, and the 2 undersigned. The workshop was once conceived out of a wish to offer a discussion board for discussions of either basal ganglia-and motor thalamus-related matters by way of bringing jointly uncomplicated scientists and clinicians representing various disciplines, study instructions, and philosophies. the first ambitions have been to motivate an alternate of data and ideas in an off-the-cuff atmosphere, to stimulate integration of the knowledge from varied disciplines, and to spot arguable concerns and the main crucial inquiries to be addressed in destiny research.

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Extra resources for Basal Ganglia and Thalamus in Health and Movement Disorders

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Abstr. 22:415. , 1999, Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates, Exp. Brain Res. 125:397. , 1983, Origins of post synaptic potentials evoked in spiny neostriatal projection neurons by thalamic stimulation in the rat, Exp Brain Res 51 :217. H .. , 1986, Role ofthe basal ganglia in the initiation of saccadic eye movements, Progre. Brain Res. 64: 175. , 1998, EEG findings in patients with vascular parkinsonism, Acta Neurol.

1989; DeLong, 1990). In the following sections we will briefly review the microcircuitry of the striatum with particular emphasis on two classes of neurons, the spiny projection neurons and GABA interneurons. For detailed discussions of the anatomical and functional organization of the basal ganglia see reviews by Gerfen and Wilson (1996) and Smith et al. (1998). , 1995; Kawaguchi, 1997). The major type of projection neuron is the medium size densely spiny neuron (spiny neuron), which accounts for 90-95% of the total population of striatal neurons (Kemp and Powell, 1971 b).

Individual spiny neurons receive a basket-like innervation around their perikarya from parvalbumin-positive terminals, the majority of which are likely to be derived from the parvalbumin-positive GABA interneurons. , 1994; Plenz and Kitai, 1998). Indeed, paired recordings in vitro have shown that GABA interneurons produce large unitary IPSPs in spiny neurons (Koos and Tepper, 1999). Although the precise role of this inhibition is unknown, there are several possibilities. First, the effect may simply be to shunt coincident cortical excitation and limit the duration of excitation (Pennartz and Kitai, 1991; Plenz and Kitai, 1998).

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Basal Ganglia and Thalamus in Health and Movement Disorders by Anne B. Young, John B. Penney (auth.), Kristy Kultas-Ilinsky, Igor A. Ilinsky (eds.)


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