Kasugai, Yu; Machtoub, Lina's Amyotrophic lateral sclerosis : advances and perspectives of PDF

By Kasugai, Yu; Machtoub, Lina

ISBN-10: 9814463051

ISBN-13: 9789814463058

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Additional info for Amyotrophic lateral sclerosis : advances and perspectives of neuro-nanomedicine

Sample text

Suspected ALS will manifest only LMN signs in two or more regions, although UMN pathology might be demonstrated at autopsy. However, only clinical signs are considered pertinent to this classification at the time of diagnostic evaluation. The clinical features that support the diagnosis of ALS include one or more of the following: 1. abnormal pulmonary function test not explained by other causes 2. abnormal speech studies not explained by other causes 3. abnormal swallowing studies not explained by other causes machtoub–ALS 49 October 23, 2015 12:42 PSP Book - 9in x 6in 50 Diagnostic Criteria of Amyotrophic Lateral Sclerosis 4.

2. 3. 4. 5. sensory dysfunction sphincter abnormalities autonomic nervous system dysfunction anterior visual pathway abnormalities movement abnormalities associated with probable Parkinson’s disease defined by DATATOP criteria 6. cognitive abnormalities associated with clinical Alzheimer’s disease as defined by NINCDS-ADRDA criteria If these clinical findings occur, then close attention should be paid to the possible diagnosis of other disease processes. LMN and UMN signs may occur together with other clinical signs in disease where the pathologic process is not primary motor neuron degeneration.

Scientists have considered viral infection for many other disorders of the nervous system, from schizophrenia to multiple machtoub–ALS October 23, 2015 12:42 PSP Book - 9in x 6in machtoub–ALS BMAA Neurotoxic Effects sclerosis, as well as for ALS. A concrete link to viral infection has never been documented in any of these diseases. The ALS Association has recognized the debate over a viral role in ALS and has funded study of the issue, but so far findings have failed to confirm any link with ALS and viral infection.

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Amyotrophic lateral sclerosis : advances and perspectives of neuro-nanomedicine by Kasugai, Yu; Machtoub, Lina


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