Download e-book for kindle: Aldol Reactions by Rainer Mahrwald

By Rainer Mahrwald

ISBN-10: 9048179580

ISBN-13: 9789048179589

Aldol Reactions offers a entire up to date evaluation of aldol reactions together with program of alternative steel enolates; catalytic aldol additions catalyzed by means of diverse Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the new competitive improvement of organocatalyzed aldol additions. the facility of every procedure is established by means of numerous purposes in overall synthesis of typical items. the professionals and cons of those methodologies in regards to stereoselectivity, regioselectivity and alertness in overall synthesis of common items are mentioned. nice value is determined to the various probabilities of the guide of aldol response to put in required configurations in complex ordinary product synthesis.

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2 Magnesium Enolates There are only a few examples of applications of magnesium enolates in aldol additions. 1). 1. t-BuMgBr/THF 2. 1 Enantioselective aldol addition of sulfinyl acetates R. V. 4 But the application of Grignard reagents in direct aldol additions is limited to special substrates as well as to special Grignard reagents. It causes side reactions, such as the reduction of aldehydes. 7 They were able to elaborate a synthesis of crystalline bis-(hexamethyldisilazido)magnesium. Moreover, they were also able to isolate a magnesium intermediate from the self aldol addition of methyl tert-butyl ketone.

Fanjul S, Hulme AN, White JW (2006) Org Lett 8:4219 39. Evans DA, Sjorgren EB, Bartroli J, Dow RL (1986) Tetrahedron Lett 27:4957 40. Evans DA, Dow RL, Shih TL, Takacs JM, Zahler R (1990) J Am Chem Soc 112:5290 41. Evans DA, Weber AE (1986) J Am Chem Soc 108:6557 42. Evans DA, Sjorgren EB, Bartroli J, Dow RL (1986) Tetrahedron Lett 27:4957 43. Evans DA, Sjorgren EB (1985) Tetrahedron Lett 26:3783 44. Abiko A (2004) Acc Chem Res 37:387 45. Evans DA, Cee V, Siska SJ (2006) J Am Chem Soc 128:9433 46.

1). 1. t-BuMgBr/THF 2. 1 Enantioselective aldol addition of sulfinyl acetates R. V. 4 But the application of Grignard reagents in direct aldol additions is limited to special substrates as well as to special Grignard reagents. It causes side reactions, such as the reduction of aldehydes. 7 They were able to elaborate a synthesis of crystalline bis-(hexamethyldisilazido)magnesium. Moreover, they were also able to isolate a magnesium intermediate from the self aldol addition of methyl tert-butyl ketone.

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Aldol Reactions by Rainer Mahrwald


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