By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)
The challenge of senescence, as mirrored within the historical past of reli gion and philosophy, has lengthy been one of many maximum issues of humankind. by contrast, gerontology as a department of technological know-how continues to be relatively younger. up to now decade, concomitant with speedy growth in our knowing of the elemental lifestyles sciences, massive shops of data approximately organic getting older were amassed. this data, even if, coming up from many clinical disciplines and curious about various degrees of biologic association, turns out virtually random and covers every little thing from molecules to human societies. Theories complicated to interpret the proof and to appreciate the mech anisms thinking about senescence have remained in person, instead of basic, territories. It has lengthy been felt through a few gerontologists that it used to be time for a few of the experts to step again and take a generalist view of gerontology, to re-examine and reevaluate the culmination in their analyt ical goals at varied degrees inside of a broader context. a few others might imagine it nonetheless untimely. It appeared, even though, that most of these who amassed in Tokyo at the social gathering of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be won in trying to find interrelationships one of the proof and theories originated within the diversified degrees of investiga tion in an try and detect and delight in the organic drama of senescence as an entity.
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Extra resources for Aging Phenomena: Relationships among Different Levels of Organization
See Fig. 15). Since the amount of 3H-Concanavalin A binding to fibroblast surfaces does not change throughout the life span of human fibroblasts, the changes in the adsorption of Concanavalin A-coated red blood cells to fibroblast surface was concluded to reflect a continuous change in the Concanavalin A receptor modulating system with aging (12). A linear progressive type of change, rather than a catastrophe type of change, is very important for gaining insight into the cellular mechanisms of aging.
The quantitative terms in both systems, such as the proportion of clonogenic cells in a culture or the time required for a direct descendant of a clonogenic cell in a cell population to become a binucleated cell, may differ, however. For senescent human lung cells, some of which are polyploid, a further model of multinucleation and polyploidization is shown in 36 MULTINUCLEATION AND POLYPLOIDIZATION OF AGING HUMAN CELLS ---+ DNA SYNTHESIS BC 4C 2C 4C BC l6C NUCLEAR DIVIS ION Fig. 4. Cell cycle and "cell spiral" model of in vitro cellular aging.
4:215, 1919. -------14. Y. Mitsui, H. Sakagami, S. Murota, and Y. Yamada, Age-related decline in Hi histone fraction in human diploid fibroblast cultures, Exp. , in press. CHANGE OF RESPONSIVENESS TO GROWTH STIMULATION OF NORMAL CELLS DURING AGING Tadao Ohno National Institute of Radiological Sciences Anagawa, Chiba-shi 260 Japan INTRODUCTION The sole determinant of life span of normal diploid cells in vitro has been considered to be the intrinsic doubling number of the cells (1,2,3). Recent investigations, however, suggest that extracellular factors can affect the proliferative potential of the cells.
Aging Phenomena: Relationships among Different Levels of Organization by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)