By S.L. Schreiber
Quantity 1 offers a close survey of reactions that entail the 1,2-addition of nonstabilized carbanion equivalents of carbonyl, imino and thiocarbonyl performance. Emphasis has been put on these reagents that bring about hugely selective addition reactions. tools are said to choose, for instance, one carbonyl workforce over one other within the related molecule, or so as to add preferentially a fraction to at least one (enantiotopic of diastereotopic) face of a carbonyl team. methods that outcome from an preliminary addition to the C=X useful staff, for instance alkenations and rearrangements, also are coated during this quantity.
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Extra resources for Additions to C-X &pgr;-Bonds, Part 1, Volume 1
E. proﬁles of changes in concentrations of starting materials and/or products with time) can be obtained. 7). The aim is to obtain realistic but imperfect preliminary kinetic data. g. >1 M ). Although this is far from ideal because the reaction medium changes as the reaction occurs, the important point is that relatively few changes in the procedure (requiring little extra effort) are required. Methods of handling the raw kinetic data are considered in Chapter 3. 1 Sampling and analysis for kinetics When data are collected automatically and calculations are also automated, hundreds of data points are often used to obtain rate constants (see Chapter 3).
If more accurate data are required, corrections can be made mathematically for small changes in the volumes injected . 7 Case studies: more detailed mechanistic evidence from product studies In this section, mechanistic investigations of details of particular reaction pathways will be considered. g. g. the SN 2 mechanism which uniﬁes a wide range of reactions such as hydrolysis of alkyl halides and quaternisation of amines; (iii) obtaining increasingly detailed knowledge about reaction intermediates and pathways.
The simplest variations are reaction time and temperature. Monitoring reactions qualitatively as they proceed is also included here, because reactions are investigated at shorter than normal reaction times. 6. First, however, some limitations need to be considered. If reaction conditions are varied, it cannot be established with certainty that the reaction mechanism does not change. 9 Competing benzyne and SRN 1 mechanisms for halotrimethylbenzenes with potassium amide in liquid ammonia. intermediates observed under changed reaction conditions would proceed to the main product under normal reaction conditions.
Additions to C-X &pgr;-Bonds, Part 1, Volume 1 by S.L. Schreiber